MSM is derived from the liquid solvent dimethyl sulfoxide (DMSO), which was a popular alternative remedy for rheumatoid arthritis and other inflammatory conditions in the 1960s and 1970s. Bathing sore joints in DMSO seemed to reduce arthritic symptoms, and there is some clinical evidence for this benefit.
Both DMSO and MSM appear to be well tolerated and have few noticeable side effects. But recent evidence suggests that they may have significant toxic effects in some cells. One report, for example, showed that MSM induced abnormalities in chromosomes and toxic damage to the gametes (egg and sperm cells) of worms.





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